结果与I/R各时相组相比,I/R+T各时相组CHIP及HSP70的mRNA水平显著升高[(0 87±0 10)vs(0 50±0

结果与I/R各时相组相比,I/R+T各时相组CHIP及HSP70的mRNA水平显著升高[(0.87±0.10)vs(0.50±0.06),(0.57±0.07)vs(0.33±0.04),(0.47±0.06)vs(0.19±0.03),P<0.01]。与I/R2、获悉更多24h组相比I/R+T组CHIP及mRNA水平显著升高[(1.15±0.12)vs(0.57±0.07),(0.81±0.09)vs(0.44±0.06),P<0.01];MG-132上调了I/R+T各时相组HSP70的蛋白质表达,与I/Rselleck chemical各组相比,差异均有统计学意义[(1.28±0.16)vs(0.79±0.08),(0.88±0.12)vs(0.58±0.12),(0.9±0.17)vs(0.50±0.09),P<0.01];MG-132上调了I/R+T2、24h组CHIselleck HSP 抑制剂P的蛋白质表达,与I/R2、24h组相比,差异有统计学意义[(1.43±0.15)vs(1.04±0.11),P<0.01;(1.16±0.11)vs(0.96±0.13)],P<0.05)。结论心肌缺血再灌注前适量静注MG-132能显著刺激缺血再灌注大鼠心脏CHIP表达,从而进一步上调HSP70水平,从而保护心肌。

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